Interleukin-8 and Matrix Metalloprotease 9 as Salivary Biomarkers of Pain in Patients with Temporomandibular Disorder Myalgia: A Pilot Study
박양미, 안용우, 정성희, 주혜민, 전혜미, 김경희, 옥수민,
소속 상세정보
박양미 ( Park Yang-Mi ) - Pusan National University Dental Hospital Department of Oral Medicine
안용우 ( Ahn Yong-Woo ) - Pusan National University Dental Hospital Department of Oral Medicine
정성희 ( Jeong Sung-Hee ) - Pusan National University Dental Hospital Department of Oral Medicine
주혜민 ( Ju Hye-Min ) - Pusan National University Dental Hospital Department of Oral Medicine
전혜미 ( Jeon Hye-Mi ) - Pusan National University Hospital Department of Oral Medicine
김경희 ( Kim Kyung-Hee ) - Inje University Busan Paik Hospital Department of Oral Medicine
옥수민 ( Ok Soo-Min ) - Pusan National University Dental Hospital Department of Oral Medicine
Abstract
Purpose: To search the salivary factors that objectively indicate an pain in myalgia patients with temporomandibular joint disorder (TMD) and determine the possibility of the factors as pain-biomarkers.
Methods: Participants consisted of pain-free 15 persons (male 7, female 8, mean age±standard deviation (SD); 26.8±16.04 years) and 45 myalgia patients with TMD (male 21, female 24, mean age±SD; 27.98±13.01 years). They were divided into a pain-free group (numerical rating scale [NRS] score 0), a mild pain group (NRS 1-4), a moderate pain group (NRS 5-6), and a severe pain group (NRS 7-10) and members of all groups were age, sex matched. Interleukin-8 (IL-8) and matrix metalloprotease 9 (MMP-9) were selected as pain biomarkers, by searching the Gene Expression Omnibus database and analyzing pain-related genes. Enzyme-linked immunosorbent assays were used to measure the concentration of IL-8 and MMP-9 in the patients’ saliva.
Results: IL-8 and MMP-9 levels were statistically significantly higher in pain groups than in the pain-free group. Greater differences were observed in patients with acute pain (with painful duration under 3 months) than in the control group and in female patients than in male.
Conclusions: Salivary IL-8 and MMP-9 may play a role as biomarkers of myalgia in patients with TMD.
키워드
Biomarkers; Interleukin-8; Matrix metalloprotease 9; Myalgia; Saliva; Temporomandibular joint disorders
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